Diagnosis Treatment and Prevention of HPV infection

Treatment Prevention and Diagnosis of HPV infection - The diagnosis of HPV infection (human papillomavirus) is performed with the following tests:

  • Macroscopic examination: involves direct observation of genital warts; you can use acetic acid, which stains white lesions. It is also observed by colposcopy of the cervix and vagina, previously stained with iodine or acetic acid.
  • Microscopic examination: observation of suspicious cells with coilocytic changes in cytology of the cervix and vagina in women, using Papanicolaou staining. Suspected lesions biopsies, or even genital warts or genital warts may be taken from both men and women, and samples may be sent to a pathology section for analysis.
  • Direct detection of the genetic material of the virus by techniques of molecular biology, which amplify the DNA of the virus and allow the identification of the different serotypes.

Treatment of HPV

Treatment of HPV (human papillomavirus) infection can vary depending on several factors, including the type of lesion (warts, precancerous or cancerous lesions), anatomical location of lesions, and a number of lesions. injuries.

Treatment of warts

The treatment of HPV-originated warts includes:

  • Topical application of podophyllin 0.5% directly on the wart, which can be applied by the same patient twice a day for three consecutive days followed by four days of rest, being able to repeat the cycle up to four times.
  • Topical application of Imiquimod to 5% (Aldara in cream on mono-dose). This immunomodulatory drug acts by activating the cells of the immune system that attack and destroy the virus. Imiquimod can be applied by the same patient, once a day before bed, three times a week, for a maximum period of 16 weeks. After six to ten hours of action, the medication should be removed from the area with plenty of soap and water. This treatment is contraindicated in pregnancy. It may present slight redness of the area and pruritus, possible indication of the activity of the immune system.
  • Application of 80-90% trichloroacetic acid: this substance is a very strong acid that should only be applied topically with an applicator in the area of the lesion by a specialist doctor, repeating the treatment once a week until eliminating the injury.

Other forms of wart removal that must be performed by medical specialists are cryotherapy with liquid nitrogen and surgical removal by electrocoagulation or by the use of laser.

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Treatment of precancerous cervical lesions

If a woman with a papillomavirus precancerous lesion receives the right treatment in time she has a high rate of healing and survival. The therapeutic approach of these lesions consists of:

  • Cryotherapy: the tissue is frozen using a metal probe that has been cooled with nitrous oxide or carbon dioxide circulating inside the probe. It has an effectiveness ranging from 85 to 95% and is only used in the case of small lesions of approximately 20 millimeters or less and that does not extend into the canal of the cervix.
  • Electro-Surgical Cleavage by Hand: involves removal of the affected area with a hot handle like the scalpel and requires the use of local anesthesia. It has a 95% effectiveness for the removal of the injury.
  • Cold conization with a scalpel: involves removing the affected cone-shaped tissue from the cervix using the scalpel. Although it is no longer the treatment of choice for precancerous lesions, it can still be used in cases of injuries that can not be treated otherwise, or when cancer is suspected. It has an effectiveness of 94%, requires the use of anesthesia, and has as main complication the bleeding of the area, as well as the risk of stenosis (narrowing) of the canal of the uterine cervix.

Treatment of papillomavirus cancerous lesions

If a person has been diagnosed with any type of cancer associated with papillomavirus infection, the behavior of the specialists will depend on the location of the lesion and the extent of the neoplasia. Treatment may include surgical procedures, chemotherapy, and radiation therapy, among others.

Micro-immunotherapy to treat HPV

Microimmunotherapy is little known among physicians however it has been applied in the world for about 35 years with good results. It was born in 1967 when Dr. Maurice Jenaer discovered that when Nucleic Acids (DNA and RNA) were administered in highly diluted proportions to cancer patients they were able to stimulate their immune system and the patient improved. Since then several types of research and studies have been carried out that have made possible the development of a therapeutic system that is used in the effective treatment of any disease, simply cooperating with the immune system.

Dr. Diego Jacques, a physician specializing in gynecology and obstetrics, homeopathic medicine and prenatal medicine, has shown, through research, that the use of very low doses of molecules that are produced by the immune system such as interleukins since 1 to 17, as well as interferon alpha, anti-HLA DR, and together with other substances like cyclosporin A, fragments RNA and DNA in very diluted doses, contributes to the improvement of the effectiveness of the immune response of the organism to the infection by HPV; this formula has been called 2L®PAPI.

To prevent HPV (human papillomavirus) infection, in addition to limiting risk factors, such as avoiding unprotected promiscuity and intercourse, specialists recommend administering the HPV vaccine.

The first vaccine developed and marketed to prevent cervical cancer, precancerous genital lesions and warts due to papillomavirus, has been available since 2006 under the name Gardasil, which consists of an injectable suspension of the purified L1 proteins of four virus serotypes: 6, 11, 16 and 18.

Gardasil is administered to female patients, aged 9 to 26 years, in three doses, allowing two months to pass between the first and second doses and four months between the second and third doses. The vaccine is given as an intramuscular injection (injection into a muscle), preferably in the arm or thigh.

The second vaccine has been available since 2009 and is called Cervarix. It contains a suspension of the major antigenic protein that comes from the capsid of oncogenic types 16 and 18, this is the L1 protein. Cervarix is a vaccine indicated for the prevention of diseases caused by oncogenic viruses 16 and 18: cervical cancer, cervical intraepithelial neoplasia (NIC) 1 and 2, as well as adenocarcinoma in situ. Its use is approved in women aged 9 to 26 years. Immunization with Cervarix is done by the application of three doses of the vaccine intramuscularly in the deltoid region of the arm at 0, 1, and 6 months.

In 2011, the US vaccine committee and the Atlanta Center for Infectious Diseases (CDC-Atlanta) recommended the use of the Gardasil vaccine against papillomavirus in male patients aged 11 to 21 years, with the age of vaccination extended to the 26 years in the case of homosexuals and men with the depressed immune system.

In December 2014, the World Health Organization (WHO) presented the new version of the Comprehensive Guide to Cervical Cancer - A Guide to Essential Practices, which recommends giving girls between the ages of 9 and 13 two doses of the vaccine compared to the papillomavirus because this vaccination schedule is just as effective as the one of three that was carried out to date and, thus, facilitates the administration of the vaccine and reduces its cost. Zotorial
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